 |
|
|
Adaptation to Nocturnal Intermittent Hypoxia in Sleep-Disordered Breathing: 2,3 Diphosphoglycerate Levels: A Preliminary Study
Levent Ozturk M.D, Banu Mansour M.D, Zerrin Pelin M.D, Firuz Celikoglu M.D, Nuran Gokhan M.D
An inexpensive method for determining significant sleep-related hypoxemia would be
beneficial for patients being investigated and treated for sleep-disordered breathing in
order to distinguish hypoxic patients from those without nocturnal hypoxemia. Since 2,3
diphosphoglycerate (DPG) which profoundly affects dissociation of O2 from hemoglobin
is an instrumental subtance in determining the O2 affinity of blood, it becomes important
to consider in what extent the nocturnal intermittent hypoxemia may change the levels of
2,3 DPG. In this study, we tested the hypothesis that 2,3 DPG levels of hypoxic SDB
patients may be higher than that of nonhypoxic SDB patients and normal controls.
Fourteen SDB patients were participated the study, seven with hypoxia (hypoxic group)
who spent more than 10 minutes during sleep with SaO2<90% (mean 71 minutes), and
seven SDB patients (nonhypoxic group) who spent less than 10 minutes during sleep with
SaO2<90% (mean 6 minutes). Seven healthy non-smoking subjects were included as a
control group. After giving informed consent, all participants underwent a venous blood
sampling performed between 07:00 and 08:00 a.m. Blood 2,3 DPG levels were measured
by using spectrophotometry. 2,3 DPG levels were 1.84�0.44, 1.68�0.18 and 1.71�0.11
mmol/mL in hypoxic, nonhypoxic and control groups respectively (p>0.05). In conclusion,
to our knowledge this is the first study that has evaluated 2,3 DPG levels in hypoxic and
non hypoxic types of SDB patients. Chronic intermittent hypoxia which is entirely a
different entity from sustained hypoxia did not lead to increases in 2,3 DPG levels in both
hypoxic and nonhypoxic SDB patients. (Sleep and Hypnosis 2002;4(4):143-148)
|
|
| To download full text of articles please |
|
|
| |
