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Sleep Microarchitecture in Depression: Association with Response to Bupropion Treatment
Geoffrey E. Ott Ph.D, Uma Rao M.D, Keh-Ming Lin M.D, Russell E. Poland Ph.D
The study examined the effect of sustained-release bupropion on sleep microarchitecture
in unipolar depression, and evaluated the relationship between the observed sleep
changes in response to a single-dose bupropion administration and clinical response to the
drug during short-term treatment. Twenty adult patients with major depressive disorder
were studied in the sleep laboratory twice for two consecutive nights. On the morning of
second night during each session, either placebo or sustained-release bupropion
(Wellbutrin SR7; 150 mg, PO) was administered. The participants then received open-label
treatment with Wellbutrin-SR for eight weeks. Bupropion produced several effects on
sleep microarchitecture. Overall, the frequency distribution of EEG was shifted towards
faster frequencies, suggesting greater desynchronization. Bupropion also increased mean
wave amplitude during REM sleep and exacerbated inter-hemispheric differences in the
number of wave peaks. Neither sleep microarchitecture measures at baseline, nor those
following bupropion administration, were related to treatment response. The lack of a
predictive microarchitecture measure for response to bupropion treatment may be due to
the modest sample size or due to its pharmacological profile of having minimal
serotonergic activity. A simultaneous study of bupropion and serotonergic agents would
be helpful in clarifying this issue. (Sleep and Hypnosis 2002;4(2):77-84)
| Keywords: depression, sleep, microarchitecture, antidepressant, bupropion, treatment |
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